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Phox-I2

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Chemical Structure| 353495-22-4 同义名 : -
CAS号 : 353495-22-4
货号 : A1466500
分子式 : C18H15N3O4
纯度 : 95%
分子量 : 337.329
MDL号 : MFCD00700947
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(741.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binding to p67phox with high affinity and with a Kd value of approximately 150 nM. Phox-I2 is a NOX2 inhibitor that inhibits the production of reactive oxygen species (ROS)[1].Phox-I2 effectively inhibits NOX2-mediated superoxide production in dHL-60 cells and primary human neutrophils in a dose-dependent manner without detectable toxicity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.82mL

2.96mL

1.48mL

29.64mL

5.93mL

2.96mL
参考文献

[1]Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19(2):228-42.