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Erastin2

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Chemical Structure| 1695533-44-8 同义名 : 35MEW28
CAS号 : 1695533-44-8
货号 : A1465562
分子式 : C36H35ClN4O4
纯度 : 98%
分子量 : 623.14
MDL号 : MFCD32867306
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(168.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Erastin2 acts as a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.02mL

1.60mL

0.80mL

16.05mL

3.21mL

1.60mL
参考文献

[1]Cao JY, et al. A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8.

[2]Dixon SJ, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 2014 May 20;3:e02523.