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BTYNB

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Chemical Structure| 304456-62-0 同义名 : BTYNB IMP1 Inhibitor;MDK6620
CAS号 : 304456-62-0
货号 : A1464578
分子式 : C12H9BrN2OS
纯度 : 97%
分子量 : 309.182
MDL号 : MFCD00977636
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(194.06 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA (IC50=5 μM). BTYNB exhibits selectivity and effectiveness against IMP1-postive cancer cell lines. BTYNB elicits a robust dose-dependent inhibition of cell proliferation in IMP1-positive cells with IC50 values of 2.3 μM, 3.6 μM, and 4.5 μM in ES-2, IGROV-1, and SK-MEL2 cells, respectively. Pretreatment with 10μM BTYNB for 72 hours enhances the degradation rate of c-Myc mRNA in SK-MEL2 cells[2]. Through impairing IGF2BP1-RNA association, BTYNB could disrupt the stabilization of E2F-driven transcripts by IGF2BP1 in cancer[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.23mL

0.65mL

0.32mL

16.17mL

3.23mL

1.62mL

32.34mL

6.47mL

3.23mL
参考文献

[1]Mahapatra L, Andruska N, Mao C, Le J, Shapiro DJ. A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation. Transl Oncol. 2017 Oct;10(5):818-827. doi: 10.1016/j.tranon.2017.07.008. Epub 2017 Aug 29. PMID: 28846937; PMCID: PMC5576976.

[2]Mahapatra L, Andruska N, Mao C, Le J, Shapiro DJ. A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation. Transl Oncol. 2017 Oct;10(5):818-827.

[3]Müller S, Bley N, Busch B, Glaß M, Lederer M, Misiak C, Fuchs T, Wedler A, Haase J, Bertoldo JB, Michl P, Hüttelmaier S. The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer. Nucleic Acids Res. 2020 Sep 4;48(15):8576-8590.