产品说明书
Zanzalintinib
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同义名 : | XL092;JUN04542 |
| CAS号 : | 2367004-54-2 | |
| 货号 : | A1463355 | |
| 分子式 : | C29H25FN4O5 | |
| 纯度 : | 99%+ | |
| 分子量 : | 528.531 | |
| MDL号 : | MFCD34179545 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 16 mg/mL(30.27 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Zanzalintinib (XL092) is an orally active ATP-competitive inhibitor targeting multiple receptor tyrosine kinases (RTKs) such as MET, VEGFR2, AXL, and MER, with respective IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays. It demonstrates anti-tumor activity and holds promise for kinase-dependent diseases and conditions research [1][2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.89mL 0.38mL 0.19mL |
9.46mL 1.89mL 0.95mL |
18.92mL 3.78mL 1.89mL |
| 参考文献 |
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