产品说明书
Tapinarof
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同义名 : | WBI-1001;Benvitimod;3,5-DH4IS;WBI 1001. GSK-2894512;WB-1001;DMVT 505;DHPS;GSK2894512 |
| CAS号 : | 79338-84-4 | |
| 货号 : | A1463321 | |
| 分子式 : | C17H18O2 | |
| 纯度 : | 97% | |
| 分子量 : | 254.324 | |
| MDL号 : | MFCD13193203 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(412.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tapinarof, also known as WBI-1001, is an AhR agonist with an EC50 value of 13 nM. Tapinarof alleviates skin inflammation in mice.Tapinarof activates the AhR pathway through direct binding. Tapinarof dose-dependently induces nuclear translocation of AhR in HaCaT cells with an EC50 value of 0.16 nM[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.93mL 0.79mL 0.39mL |
19.66mL 3.93mL 1.97mL |
39.32mL 7.86mL 3.93mL |
| 参考文献 |
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