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Thalidomide-NH-C6-NH2 HCl

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Chemical Structure| 2375194-37-7 同义名 : Thalidomide-NH-C6-NH2 hydrochloride
CAS号 : 2375194-37-7
货号 : A1463116
分子式 : C19H25ClN4O4
纯度 : 95%
分子量 : 408.879
MDL号 : MFCD31729298
存储条件:

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(293.49 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Thalidomide-NH-C6-NH2 hydrochloride is a synthesized conjugate comprising an E3 ligase ligand-linker that integrates the cereblon ligand based on Thalidomide and a linker employed in PROTAC technology[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.24mL

12.23mL

2.45mL

1.22mL

24.46mL

4.89mL

2.45mL

参考文献

[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.