产品说明书

Sofpironium bromide

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Chemical Structure| 1628106-94-4 同义名 : BBI 4000
CAS号 : 1628106-94-4
货号 : A1461416
分子式 : C22H32BrNO5
纯度 : 98%
分子量 : 470.397
MDL号 : MFCD34469175
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(223.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sofpironium bromide, also known as BBI 4000, is an anticholinergic drug used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high affinity for the M1, M2, M4, and M5 isoforms. Sofpironium bromide is metabolised primarily by non-enzymatic hydrolysis, but also oxidatively by CYP2D6 and CYP3A4. Sofpironium bromide has anticholinergic activity and inhibits the activity of guinea pig ileal tissue in a concentration-dependent manner. Sofpironium bromide has anticholinergic activity and inhibits the contractile activity of guinea pig ileum tissue in a concentration-dependent manner. In a rat model, Sofpironium bromide reduced footpad sweating induced by pilocarpine, a muscarinic receptor agonist[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.63mL

2.13mL

1.06mL

21.26mL

4.25mL

2.13mL
参考文献

[1]Julia Paik, et al. Sofpironium Bromide: First Approval. Drugs. 2020 Dec;80(18):1981-1986.