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Sulforaphane

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Chemical Structure| 4478-93-7 同义名 : SFN
CAS号 : 4478-93-7
货号 : A1456978
分子式 : C6H11NOS2
纯度 : 99%+
分子量 : 177.288
MDL号 : MFCD00198068
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(338.43 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(282.03 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Sulforaphane, naturally present in widely consumed vegetables, enhances tumor suppressor protein transcription, inhibits histone deacetylase activity, activates Nrf2, and inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling. It exhibits both anti-cancer and anti-inflammatory activities [1][2][3][4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.64mL

1.13mL

0.56mL

28.20mL

5.64mL

2.82mL

56.41mL

11.28mL

5.64mL
参考文献

[1]Gamet-Payrastre L, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 2000 Mar 1;60(5):1426-33.

[2]Li B, et al. Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. Int J Mol Med. 2015 Jul;36(1):53-64.

[3]Zhang Y, et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornylisothiocyanates. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50.

[4]Chen X, et al. Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of PancreaticCancer via AMPK Dependent Signaling. ell Physiol Biochem. 2018;50(3):1201-1215.