Erastin

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Chemical Structure| 571203-78-6 同义名 : -
CAS号 : 571203-78-6
货号 : A145112
分子式 : C30H31ClN4O4
纯度 : 99%+
分子量 : 547.045
MDL号 : MFCD09837984
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(21.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

5%DMSO+40%PEG 300+5%Tween80+water 1.75 mg/mL

生物活性
描述 Erastin is an inducer of ferroptosis, initiating cell death through mechanisms involving reactive oxygen species (ROS) and iron-dependent pathways. It targets and inhibits the voltage-dependent anion channels (VDAC2/VDAC3), which leads to an increase in oxidation and subsequently, a buildup of ROS within cells. Furthermore, Erastin interferes with the mitochondrial permeability transition pore (mPTP), displaying anti-tumor properties[1].[2].[3].
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
human A673 cells Function assay Induction of cell death in human A673 cells, EC50=30 μM. 17568748
human BJ cells Function assay Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of PD-98059 by trypan blue exclusion method, IC50=0.9 μM. 17568748
human BJ cells Function assay Induction of cell death in TERT expressing human BJ cells, EC50=10 μM. 17568748
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.14mL

1.83mL

0.91mL

18.28mL

3.66mL

1.83mL
参考文献

[1]Li Y, et al. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. Hum Reprod. 2021 Mar 18;36(4):951-964.

[2]Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605.

[3]Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79.