AM 374

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Chemical Structure| 86855-26-7 同义名 : -
CAS号 : 86855-26-7
货号 : A1446919
分子式 : C16H33FO2S
纯度 : 98%+
分子量 : 308.495
MDL号 : -
存储条件：

Pure form Inert atmosphere,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(340.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AM 374 functions as a fatty acid amide hydrolase (FAAH) inhibitor, with an IC50 value of 13 nM for amidase activity inhibition. It is applicable in neurological disease research[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.24mL

0.65mL

0.32mL

16.21mL

3.24mL

1.62mL

32.42mL

6.48mL

3.24mL
参考文献

[1]Deutsch DG, et al. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun. 1997 Feb 3;231(1):217-21.

[2]Arizzi MN, et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. Life Sci. 2004 Jan 9;74(8):1001-11.