产品说明书

	同义名 :	-
	CAS号 :	2193462-87-0
	货号 :	A1440974
	分子式 :	C21H28N4O3S
	纯度 :	97%
	分子量 :	416.537
	MDL号 :	N/A
	存储条件：	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Melatonin Biotin is compound conjunct melatonin with biotin. Melatonin inhibits the inflammation and apoptosis in rats with diabetic retinopathy by repressing the MAPK (mitogen-activated protein kinase) pathway[1]. Melatonin application had no significant effect on leptin production in the kidney tissues of diabetic rats[2]. Melatonin (1.25, 5, 20 mg/kg) protects against AIF(apoptosis-inducing factor)-dependent cell death during APAP (Acetaminophen)-induced acute liver failure through its direct inhibition of hepatic RIP1 (receptor interacting protein 1) and subsequent JNK (c-Jun N-terminal kinase) phosphorylation and mitochondrial Bax translocation[3]. VD3 (1,25-dihydroxyvitamin D3) combined with Mel (Melatonin) significantly reduced apoptotic and histological alterations when compared with Mel or VD3 alone[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.40mL 0.48mL 0.24mL	12.00mL 2.40mL 1.20mL	24.01mL 4.80mL 2.40mL

参考文献

[1]Ma Y, Zhao Q, Shao Y, Cao MZ, Zhao M, Wang D. Melatonin inhibits the inflammation and apoptosis in rats with diabetic retinopathy via MAPK pathway. Eur Rev Med Pharmacol Sci. 2019 Aug;23(3 Suppl):1-8 [2]Elis Yildiz S, Deprem T, Karadag Sari E, Bingol SA, Koral Tasci S, Aslan S, Nur G, Sozmen M. Immunohistochemical distribution of leptin in kidney tissues of melatonin treated diabetic rats. Biotech Histochem. 2015 May;90(4):270-7 [3]Liang YL, Zhang ZH, Liu XJ, Liu XQ, Tao L, Zhang YF, Wang H, Zhang C, Chen X, Xu DX. Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure. PLoS One. 2012;7(12):e51911 [4]Sinanoglu O, Sezgin G, Ozturk G, Tuncdemir M, Guney S, Aksungar FB, Yener N. Melatonin with 1,25-dihydroxyvitamin D3 protects against apoptotic ischemia-reperfusion injury in the rat kidney. Ren Fail. 2012;34(8):1021-6