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NVP-BAW2881

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Chemical Structure| 861875-60-7 同义名 : BAW2881
CAS号 : 861875-60-7
货号 : A142514
分子式 : C22H15F3N4O2
纯度 : 98%
分子量 : 424.375
MDL号 : MFCD30343850
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(82.47 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • VEGFR1

    hVEGFR1, IC50:820 nM

  • VEGFR3

    hVEGFR3, IC50:420 nM

  • VEGFR2

    hVEGFR2, IC50:9 nM

    mVEGF2, IC50:165 nM
描述 BAW2881 is a vascular endothelial growth factor (VEGF) receptor tyrosine-kinase inhibitor that potently inhibits VEGFR1-3 at 1.0-4.3 nanomolar (nM) concentrations and inhibits PDGFRβ, c-Kit, and RET at 45-72 nM concentrations.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.56mL

4.71mL

2.36mL
参考文献

[1]Bold G, Schnell C, et al. A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis. J Med Chem. 2016 Jan 14;59(1):132-46.

[2]Halin C, Fahrngruber H, et al. Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol. 2008 Jul;173(1):265-77.