产品说明书
Adenosine 5′-monophosphate disodium salt
 |
同义名 : | 5‘-腺嘌呤核苷酸二钠盐 ;Adenosine 5'-monophosphate disodium |
| CAS号 : | 4578-31-8 | |
| 货号 : | A141922 | |
| 分子式 : | C10H12N5Na2O7P | |
| 纯度 : | 95% | |
| 分子量 : | 391.185 | |
| MDL号 : | MFCD00065023 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 100 mg/mL(255.63 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Adenosine 5'-triphosphatedisodium salt hydrate is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation[1]. ATP disodium salt hydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs. Furthermore, doxycycline addition markedly inhibited inflammasome activation and IL-1β production induced by a combination of P. gingivalis-LPS and ATP[2]. ATP disodium salt hydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner. ATP disodium salt hydrate stimulates cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis. ATP disodium salt hydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.56mL 0.51mL 0.26mL |
12.78mL 2.56mL 1.28mL |
25.56mL 5.11mL 2.56mL |
| 参考文献 |
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