(E)-Methyl 4-coumarate

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Chemical Structure| 19367-38-5 同义名 : 4-羟基肉桂酸甲酯 ;Methyl trans-p-Coumarate;Methyl 4-hydroxycinnamate;pCAME;trans-para-Coumaric Acid methyl ester;trans-p-Coumaric Acid methyl ester;trans-4-Coumaric Acid methyl ester
CAS号 : 19367-38-5
货号 : A141299
分子式 : C10H10O3
纯度 : 98%
分子量 : 178.185
MDL号 : MFCD00157167
存储条件：

Pure form Inert atmosphere,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(589.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Methyl trans-p-Coumarate found in several plants, such as green onion (Allium cepa) or noni (Morinda citrifolia L.) leaves. Phytochemicals, viz., methyl trans-p-coumarate (AIC-1), methyl caffeate (AIC-2), syringic acid (AIC-3), and ursolic acid (UA), at different concentrations (500, 750, and 1000 ppm) were tested on spore germination of Alternaria alternata, Curvularia lunata, Fusarium moniliforme, F. pallidoroseum, and Helminthosporium sp. Significant growth inhibition was observed against all fungi except A. alternata which was found to be resistant to AIC-3[3]. Bifidobacterium animalis subsp. lactis, Lactobacillus gasseri, Lactobacillus acidophilus, Lactobacillus plantarum and Lactobacillus fermentum displayed activities against a broad substrate range (methyl caffeate, methyl trans-p-coumarate, chlorogenic acid as well as partially ethyl ferulate) [4]. The most active AIM-C (methanol extract chloroform) fraction was repeatedly chromatographed to yield four known compounds, methyl trans-p-coumarate (1), methyl caffeate (2), syringic acid (3) and pinellic acid (4). Cell viability assay of 1-4 against U87MG cells indicated 2 as most active (IC50 value of 8.2 μg/mL), whereas the other three compounds were much less active. Compounds 1-4 were non-toxic towards normal human cells (HEK-293) [5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.61mL

1.12mL

0.56mL

28.06mL

5.61mL

2.81mL

56.12mL

11.22mL

5.61mL
参考文献

[1]Tan EM, Amirjalayer S, et al. Conformational heterogeneity of methyl 4-hydroxycinnamate: a gas-phase UV-IR spectroscopic study. J Phys Chem B. 2013 May 2;117(17):4798-805.

[2]Shimada D, Kusaka R, et al. Nonradiative decay dynamics of methyl-4-hydroxycinnamate and its hydrated complex revealed by picosecond pump-probe spectroscopy. Phys Chem Chem Phys. 2012 Jul 7;14(25):8999-9005.

[3]Shaik AB, Ahil SB, Govardhanam R, et al. Antifungal Effect and Protective Role of Ursolic Acid and Three Phenolic Derivatives in the Management of Sorghum Grain Mold Under Field Conditions. Chem Biodivers. 2016;13(9):1158-1164

[4]Fritsch C, Jänsch A, Ehrmann MA, Toelstede S, Vogel RF. Characterization of Cinnamoyl Esterases from Different Lactobacilli and Bifidobacteria. Curr Microbiol. 2017;74(2):247-256

[5]Khan RS, Senthi M, Rao PC, et al. Cytotoxic constituents of Abutilon indicum leaves against U87MG human glioblastoma cells. Nat Prod Res. 2015;29(11):1069-1073