生物活性 | |||
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描述 | Chlorquinaldol, is a derivative of 8-hydroxyquinoline which is usually administered topically for the treatment of skin infections, alone or in combination with diflucortolone valerate. in vitro,staphylococci was most sensitive to chlorquinaldol, with MIC-values ranging from 0.016 to 0.5 mg/L. A lower activity was observed against Gram-negative bacteria, with 77% of the isolates being inhibited at concentrations ranging from 128 to 512 mg/L[3]. in vitro, for 0.1 to 0.2% (W/V) chlorquinaldol concentrations, a reduction of about 10 (4) organisms was obtained after 60 minutes for N. gonorrhoeae and C. trachomatis[4]. |
临床研究 | |||||
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01153958 | Vaginosis, Bacterial | Phase 4 | Terminated | - | China ... 展开 >> Peking University People's Hospital Beijing, China Second Hospital of West China Medical School, Sichuan University Chengdu, China Obstetrics & Gynaecology Hospital of Fudan University Shanghai, China Peking University Shenzhen Hospital Shenzhen, China Wuhan Union Hospital of China Wuhan, China 收起 << |
NCT01153958 | - | Terminated | - | - |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.38mL 0.88mL 0.44mL |
21.92mL 4.38mL 2.19mL |
43.85mL 8.77mL 4.38mL |
参考文献 |
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