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Chlorquinaldol

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Chemical Structure| 72-80-0 同义名 : Chloquinan
CAS号 : 72-80-0
货号 : A140767
分子式 : C10H7Cl2NO
纯度 : 98%
分子量 : 228.075
MDL号 : MFCD00023984
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(219.23 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Chlorquinaldol, is a derivative of 8-hydroxyquinoline which is usually administered topically for the treatment of skin infections, alone or in combination with diflucortolone valerate. in vitro，staphylococci was most sensitive to chlorquinaldol, with MIC-values ranging from 0.016 to 0.5 mg/L. A lower activity was observed against Gram-negative bacteria, with 77% of the isolates being inhibited at concentrations ranging from 128 to 512 mg/L[3]. in vitro, for 0.1 to 0.2% (W/V) chlorquinaldol concentrations, a reduction of about 10 (4) organisms was obtained after 60 minutes for N. gonorrhoeae and C. trachomatis[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01153958 Vaginosis, Bacterial Phase 4 Terminated - China ... 展开 >> Peking University People's Hospital Beijing, China Second Hospital of West China Medical School, Sichuan University Chengdu, China Obstetrics & Gynaecology Hospital of Fudan University Shanghai, China Peking University Shenzhen Hospital Shenzhen, China Wuhan Union Hospital of China Wuhan, China 收起 <<
NCT01153958 - Terminated - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.38mL

0.88mL

0.44mL

21.92mL

4.38mL

2.19mL

43.85mL

8.77mL

4.38mL
参考文献

[1]Corrihons I, Dutilh B, et al. [In vitro activity of an antiseptic, chlorquinaldol, against Neisseria gonorrhoeae and Chlamydia trachomatis] . Pathol Biol (Paris). 1991 Feb;39(2):136-9.

[2]Mett H, Gyr K, et al. Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs. Antimicrob Agents Chemother. 1984 Jul;26(1):35-8.

[3]Bortolin M, Bidossi A, De Vecchi E, Avveniente M, Drago L. In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue Infections: Comparative Evaluation with Gentamicin and Fusidic Acid. Front Microbiol. 2017;8:1039. Published 2017 Jun 8.

[4]Corrihons I, Dutilh B, Bébéar C. Activité in vitro d'un antiseptique, le chlorquinaldol, sur Neisseria gonorrhoeae et Chlamydia trachomatis [In vitro activity of an antiseptic, chlorquinaldol, against Neisseria gonorrhoeae and Chlamydia trachomatis]. Pathol Biol (Paris). 1991;39(2):136-139.