3-Amino-1-propanesulfonic Acid
产品说明书
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同义名 : | 3-氨基丙烷磺酸;高牛黄酸;3-氨基-1-丙烷磺酸 ;Tramiprosate;Homotaurine;Tramiprosate, Tramiprosate Na, Tramiprosate sodium, Alzhemed, Homotaurine, NC-758, NC 758, NC758;3-Sulfopropylamine;NSC 77071;NC 758;NC 531;Alzhemed |
| CAS号 : | 3687-18-1 | |
| 货号 : | A140624 | |
| 分子式 : | C3H9NO3S | |
| 纯度 : | 98% | |
| 分子量 : | 139.173 | |
| MDL号 : | MFCD00008225 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 1 mg/mL(7.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 20 mg/mL(143.71 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Tramiprosate targets soluble Aβ, interacts with Aβ peptide and prevents its aggregation. Tramiprosate favours tau aggregation, in tau transfected non-neuronal cells, and in neuronal cells. It does not affect the binding of tau to microtubules but may prevent the formation of tau-actin aggregates[4]. Tramiprosate was found to maintain Aβ in a non-fibrillar form, to decrease Aβ42-induced cell death in neuronal cell cultures, and to inhibit amyloid deposition. It can cross the murine blood-brain barrier (BBB) to exert its activity. Treatment of TgCRND8 mice with Tramiprosate resulted in significant reduction (∼30%) in the brain amyloid plaque load and a significant decrease in the cerebral levels of soluble and insoluble Aβ40 and Aβ42 (∼20–30%). Tramiprosate influenced the central pool of Aβ, changing either its efflux or its metabolism in the brain, as a reduction up to 60% of plasma Aβ levels was observed[5]. | ||
| 作用机制 | Tramiprosate is a sulfated glycosaminoglycan mimetic which can interact with Aβ peptide, preventing its aggregation.[4] | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
7.19mL 1.44mL 0.72mL |
35.93mL 7.19mL 3.59mL |
71.85mL 14.37mL 7.19mL |
| 参考文献 |
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