产品说明书

	同义名 :	TRB-N0224
	CAS号 :	1255639-43-0
	货号 :	A1399239
	分子式 :	C26H21NO5
	纯度 :	99%+
	分子量 :	427.449
	MDL号 :	-
	存储条件：	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

CMC2.24 is an orally active tricarbonylmethane agent that is effective against pancreatic tumours in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs, with IC50 values ranging from 2-69 μM. CMC2.24 restores chondrogenic homeostasis via the NF-κB/HIF-2α axis and CMC2.24 can restore cartilage homeostasis through the NF-κB/HIF-2α axis and inhibit chondrocyte apoptosis, thereby alleviating the progression of osteoarthritis[1][2][3].CMC2.24 reduces p-STAT3-Ser727 levels and induces mitochondrial reactive oxygen species and mitochondrial cell death in pancreatic cancer cells. CMC2.24 induces mitochondrial reactive oxygen species and intrinsic cell apoptosis. CMC2.24 inhibits the growth of pancreatic cancer in vitro at concentrations of 0-60 μM for 24 hours[1].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.34mL 0.47mL 0.23mL	11.70mL 2.34mL 1.17mL	23.39mL 4.68mL 2.34mL

参考文献

[1]Mallangada NA, et al. A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras. Mol Carcinog. 2018;57(9):1130-1143. [2]Zhou Y, et al. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. J Mol Med (Berl). 2020;98(10):1479-1491. [3]Zhang Y, et al. Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins. Curr Med Chem. 2012;19(25):4348-4358.