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Stafib-2

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Chemical Structure| 2097938-74-2 同义名 : -
CAS号 : 2097938-74-2
货号 : A1398970
分子式 : C28H26N2O12P2
纯度 : 98%+
分子量 : 644.46
MDL号 : -
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(77.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b, with IC50 values of 82 nM for STAT5b and 1.7 μM for STAT5a. Stafib-2 has a very high affinity for STAT5b (Ki=8.8 nM). Stafib-2 has poor cell permeability, and at concentrations of 3-10 μM for 4-48 h, Stafib-2 was found to have a very low cellular permeability. Stafib-2 has poor cell permeability and does not show significant activity in K562 and MDA-MB-231 cells at concentrations of 3-10 μM for 4-48 h[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.55mL

0.31mL

0.16mL

7.76mL

1.55mL

0.78mL

15.52mL

3.10mL

1.55mL
参考文献

[1]Elumalai N, et, al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7(1):819.