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OTS193320

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Chemical Structure| 2093401-33-1 同义名 : -
CAS号 : 2093401-33-1
货号 : A1398852
分子式 : C28H30ClN5O4
纯度 : 98%+
分子量 : 536.022
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(111.94 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 OTS193320 is an inhibitor of SUV39H2 methyltransferase activity. OTS193320 reduces global histone H3 lysine 9 trimethylation levels and triggers apoptosis in breast cancer cells. The combination of OTS193320 and Doxorubicin reduced γ-H2AX levels and cancer cell viability compared to OTS193320 or Doxorubicin alone. In the concentration range of 0.125-0.5 μM for 24 h, OTS193320 showed growth inhibitory effect on breast cancer cell lines. OTS193320 showed high inhibitory effect on SUV39H2 enzyme activity (IC50=22.2 nM) and growth inhibitory effect on SUV39H2 positive A549 lung cancer cells (IC50=0.38 μM). At a concentration of 0.5 μM for 48 hours, OTS193320 induced apoptosis in breast cancer cells. In the concentration range of 0.125-0.5 μM for 24 hours, OTS193320 reduced H3K9me3 levels in a dose-dependent manner[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.33mL

1.87mL

0.93mL

18.66mL

3.73mL

1.87mL
参考文献

[1]Theodore Vougiouklakis, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.