产品说明书

IMB-301

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Chemical Structure| 64009-84-3 同义名 : -
CAS号 : 64009-84-3
货号 : A1398799
分子式 : C19H17Cl2FN2O
纯度 : 98%
分子量 : 379.255
MDL号 : MFCD34179474
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(276.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 IMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G), interrupts the hA3G-Vif interaction, and inhibits Vif-mediated degradation of hA3G. IMB-301 inhibits HIV-1 replication in H9 cells (IC50=8.63 uM)[1].IMB-301 is able to increase the viral envelope of hA3G by affecting the degradation of hA3G by Vif, resulting in hA3G-dependent anti-HIV activity. IMB-301 binds to hA3G, restores hA3G expression in the presence of Vif, and inhibits HIV-1 replication in an hA3G-dependent manner[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.18mL

2.64mL

1.32mL

26.37mL

5.27mL

2.64mL
参考文献

[1]Ma L, et al. Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep. 2018;8(1):8067. Published 2018 May 23.