NIBR0213
产品说明书
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同义名 : | - |
| CAS号 : | 1233332-14-3 | |
| 货号 : | A1395996 | |
| 分子式 : | C27H29ClN2O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 464.984 | |
| MDL号 : | MFCD25977008 | |
| 存储条件： |
Pure form Sealed in dry,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | NIBR-0213 emerges as a potent, orally active antagonist of the S1P1 receptor, demonstrating efficacy in experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. NIBR-0213 exhibits remarkable potency and selectivity towards S1P1 across species, with IC50 values of 2.0 nM and 2.3 nM in human and rat S1P1 receptors, respectively, in GTPγ35S assays[1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.15mL 0.43mL 0.22mL |
10.75mL 2.15mL 1.08mL |
21.51mL 4.30mL 2.15mL |
| 参考文献 |
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