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NIBR0213

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Chemical Structure| 1233332-14-3 同义名 : -
CAS号 : 1233332-14-3
货号 : A1395996
分子式 : C27H29ClN2O3
纯度 : 99%+
分子量 : 464.984
MDL号 : MFCD25977008
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 NIBR-0213 emerges as a potent, orally active antagonist of the S1P1 receptor, demonstrating efficacy in experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. NIBR-0213 exhibits remarkable potency and selectivity towards S1P1 across species, with IC50 values of 2.0 nM and 2.3 nM in human and rat S1P1 receptors, respectively, in GTPγ35S assays[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.75mL

2.15mL

1.08mL

21.51mL

4.30mL

2.15mL
参考文献

[1]Jean Quancard, et al. A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis. Chem Biol. 2012 Sep 21;19(9):1142-51.