产品说明书

Zabedosertib

Print
Chemical Structure| 1931994-81-8 同义名 : BAY 1834845
CAS号 : 1931994-81-8
货号 : A1388394
分子式 : C20H21F3N4O4S
纯度 : 99%+
分子量 : 470.465
MDL号 : MFCD32900903
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(255.07 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Zabedosertib (BAY 1834845) is a selective, orally active IRAK4 inhibitor with an IC50 of 3.55 nM, showing immunomodulatory potential. IRAK4 is a kinase integral to signaling innate immune responses from Toll-like receptors [1]. Zabedosertib also exhibits anti-inflammatory properties against IL-β, LPS, and Imiquimod-induced inflammation [2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.63mL

2.13mL

1.06mL

21.26mL

4.25mL

2.13mL
参考文献

[1]Bothe, Ulrich; Siebenreicher, Holger; Schmidt, Nicole; Nubbemeyer, Reinhard; Boemer, Ulf; Guenther, Judith; Steuber, Holger; Lange, Martin; Stegmann, Christian; Sutter, Andreas; et al.New substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs.WO2016083433A1

[2]Li Q, et al., Oral IRAK4 inhibitor BAY-1834845 prevents acute respiratory distress syndrome. Biomed Pharmacother. 2022 Sep;153:113459.

[3]Bothe U, et al., Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839. J Med Chem. 2024 Jan 25;67(2):1225-1242.