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Pranoprofen

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Chemical Structure| 52549-17-4 同义名 : Y 8004;Pyranoprofen
CAS号 : 52549-17-4
货号 : A138748
分子式 : C15H13NO3
纯度 : 98%
分子量 : 255.269
MDL号 : MFCD00866111
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(411.33 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+30% PEG300+water 11 mg/mL clear

PO 0.5% CMC-Na 35 mg/mL suspension

生物活性
靶点

  • COX
描述 Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology. Pranoprofen 0.1% was found to be as effective as diclofenac sodium 0.1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery[3]. Pranoprofen has efficacy equivalent to a moderate-potency corticosteroid with a better safety profile. It should be considered for the treatment of chronic conjunctivitis of presumed nonbacterial origin[4]. Pranoprofen inhibited ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Moreover, pranoprofen inhibited ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.92mL

0.78mL

0.39mL

19.59mL

3.92mL

1.96mL

39.17mL

7.83mL

3.92mL
参考文献

[1]Li YH, Wen Q, Fan TJ, et al. Dose dependent cytotoxicity of pranoprofen in cultured human corneal endothelial cells by inducing apoptosis. Drug Chem Toxicol. 2015 Jan;38(1):16-21.

[2]Hosoi T, Sasaki M, et al. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int. 2009 Jan;54(1):1-6.

[3]Akyol-Salman I, Leçe-Sertöz D, Baykal O. Topical pranoprofen 0.1% is as effective anti-inflammatory and analgesic agent as diclofenac sodium 0.1% after strabismus surgery. J Ocul Pharmacol Ther. 2007;23(3):280-283

[4]Notivol R, Martínez M, Bergamini MV. Treatment of chronic nonbacterial conjunctivitis with a cyclo-oxygenase inhibitor or a corticosteroid. Pranoprofen Study Group. Am J Ophthalmol. 1994;117(5):651-656

[5]Hosoi T, Sasaki M, Baba S, Ozawa K. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int. 2009;54(1):1-6