生物活性 | |||
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描述 | Tempol functions as a broad-spectrum mimetic of SOD, effectively counteracting ROS[1]. Tempol markedly reduces the decline in mitochondrial respiration and the surge in LDH release from rat PT cells caused by H2O2, suggesting a decrease in cellular damage and mortality. The protective effects of Tempol are akin to those seen with the Fe2+ chelator DEF. Nonetheless, the simultaneous administration of DEF and Tempol does not enhance the protective effects against kidney ischemia/reperfusion injury or oxidative stress-induced injury/death of PT cells[2]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
5.81mL 1.16mL 0.58mL |
29.03mL 5.81mL 2.90mL |
58.06mL 11.61mL 5.81mL |
参考文献 |
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