SM-102

产品说明书

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Chemical Structure| 2089251-47-6 同义名 : Lipid H
CAS号 : 2089251-47-6
货号 : A1376656
分子式 : C44H87NO5
纯度 : 97%
分子量 : 710.165
MDL号 : MFCD34167521
存储条件:

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(147.85 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(140.81 mM),注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇

动物实验配方:
生物活性
描述 SM-102 is an amino cationic lipid employed in lipid nanoparticle (LNP) formation, known for its superior transfection efficiency. It is pivotal for enhancing the efficacy of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.41mL

0.28mL

0.14mL

7.04mL

1.41mL

0.70mL

14.08mL

2.82mL

1.41mL

参考文献

[1]Staci Sabnis, et al. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519.

[2]Escalona-Rayo O, et al. In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy. Biomed Pharmacother. 2023 Sep;165:115065.