产品说明书
LY-2584702 tosylate salt
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同义名 : | LY2584702 Tosylate;LY2584702 (tosylate);LYS6K2 |
| CAS号 : | 1082949-68-5 | |
| 货号 : | A137621 | |
| 分子式 : | C28H27F4N7O3S | |
| 纯度 : | 99%+ | |
| 分子量 : | 617.618 | |
| MDL号 : | MFCD29054739 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 9 mg/mL(14.57 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | In the S6K1 enzyme assay, LY-2584702 (LY2584702) demonstrates an IC50 of 2 nM. The IC50 for pS6 inhibition in cells is 100 nM. At higher concentrations, LY-2584702 exhibits activity against S6K-related kinases MSK2 and RSK (enzyme assay IC50=58-176 nM). It dose-dependently reduces S6K activity in EOMA cells, as indicated by decreased phosphorylation of the downstream target S6[2]. LY-2584702 (LY2584702) significantly reduces A549 cell proliferation after 24 hours at a concentration of 0.1 μM (P<0.05), with the decrease becoming more pronounced with extended treatment duration and/or higher drug doses (all P<0.05). Comparable effects are seen in SK-MES-1 cells, though a clear reduction requires LY-2584702 at 0.6 μM (P<0.05), a significantly higher dose than for A549[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.62mL 0.32mL 0.16mL |
8.10mL 1.62mL 0.81mL |
16.19mL 3.24mL 1.62mL |
| 参考文献 |
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