ALC-0315
产品说明书
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同义名 : | - |
| CAS号 : | 2036272-55-4 | |
| 货号 : | A1375212 | |
| 分子式 : | C48H95NO5 | |
| 纯度 : | 97% | |
| 分子量 : | 766.272 | |
| MDL号 : | MFCD33402175 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(65.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 无水乙醇: 100 mg/mL(130.5 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | ALC-0315 is an ionizable aminolipid responsible for mRNA compaction, aiding in mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be utilized to form lipid nanoparticle (LNP) delivery vehicles, which have been employed in mRNA COVID-19 vaccine research [1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.30mL 0.26mL 0.13mL |
6.53mL 1.30mL 0.65mL |
13.05mL 2.61mL 1.30mL |
| 参考文献 |
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