ARS-1323-alkyne

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Chemical Structure| 2436544-27-1 同义名 : -
CAS号 : 2436544-27-1
货号 : A1374007
分子式 : C28H27ClF2N6O3
纯度 : 98%
分子量 : 569.002
MDL号 : MFCD32067946
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(439.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, serves as a conformation-specific chemical reporter of the nucleotide state of KRASG12C in living cells[1]. ARS-1323-alkyne is a click chemistry reagent containing an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.79mL

1.76mL

0.88mL

17.57mL

3.51mL

1.76mL
参考文献

[1]Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450.