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Diflapolin

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Chemical Structure| 724453-98-9 同义名 : -
CAS号 : 724453-98-9
货号 : A1373802
分子式 : C22H17Cl2N3O2S
纯度 : 97%
分子量 : 458.36
MDL号 : MFCD04092440
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(185.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Diflapolin acts as a potent dual inhibitor of 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH), showcasing significant anti-inflammatory effectiveness and high specificity for its targets. It prevents the formation of 5-LOX products in human monocytes and neutrophils with IC50 values of 30 nM and 170 nM, respectively, and also inhibits the activity of isolated sEH with an IC50 of 20 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.91mL

2.18mL

1.09mL

21.82mL

4.36mL

2.18mL
参考文献

[1]Garscha U, et al. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017;7(1):9398. Published 2017 Aug 24.