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Dehydroevodiamine HCl

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Chemical Structure| 111664-82-5 同义名 : Dehydroevodiamine (hydrochloride);Dehydroevodiamine hydrochloride
CAS号 : 111664-82-5
货号 : A137270
分子式 : C19H16ClN3O
纯度 : 99%+
分子量 : 337.803
MDL号 : MFCD32061978
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(35.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(2.96 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
靶点

  • AChE
描述 Dehydroevodiamine (DHE) Hydrochloride (HCl) is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities. DHE administration had an excellent therapeutic impact on the AIA (adjuvant-induced arthritis) rat model, substantially relieving joint swelling, inhibiting synovial pannus hyperplasia, and decreasing joint scores[2]. DHE suppressed the viability of HCT116, CT26, SW480, and LoVo cells. DHE treatment led to G2/M arrest via a reduction of cyclin B1/CDK1 and caspase-dependent apoptosis. It also induced autophagy by regulating LC3-II and beclin-1 expression. Additionally, migration and invasion of CRC cells were decreased by DHE through regulation of the expression of EMT markers. Oral administration of DHE could inhibit the lung metastasis of CT26 cells in an in vivo model[3]. A single (20 mg/kg p.o.) and repeated (10 mg/kg p.o.) administrations of DHED (dehydroevodiamine.HCl) could significantly reverse the latency time shortened by scopolamine (1 mg/kg i.p.) to control level. The cognitive deficits caused by EC lesion and middle cerebral artery occlusion were improved significantly by repeated administrations of DHED (6.25 mg/kg i.p.) after EC lesion or ischemic insult once a day for 7 days in the passive avoidance test[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.80mL

2.96mL

1.48mL

29.60mL

5.92mL

2.96mL
参考文献

[1]Haji A, Momose Y, et al. Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa. J Nat Prod. 1994 Mar;57(3):387-9.

[2]Dai Y, Sheng J, He S, Wu Q, Wang Y, Su L. Dehydroevodiamine suppresses inflammatory responses in adjuvant-induced arthritis rats and human fibroblast-like synoviocytes. Bioengineered. 2022 Jan;13(1):268-279

[3]Jeon HD, Han YH, Mun JG, Yoon DH, Lee YG, Kee JY, Hong SH. Dehydroevodiamine inhibits lung metastasis by suppressing survival and metastatic abilities of colorectal cancer cells. Phytomedicine. 2022 Feb;96:153809

[4]Park CH, Lee YJ, Lee SH, Choi SH, Kim HS, Jeong SJ, Kim SS, Suh YH. Dehydroevodiamine.HCl prevents impairment of learning and memory and neuronal loss in rat models of cognitive disturbance. J Neurochem. 2000 Jan;74(1):244-53