产品说明书

KG5

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Chemical Structure| 877874-85-6 同义名 : -
CAS号 : 877874-85-6
货号 : A1371593
分子式 : C20H16F3N7OS
纯度 : 97%
分子量 : 459.448
MDL号 : MFCD27665470
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(228.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 KG5 is an orally active dual inhibitor of PDGFRβ and B-Raf through allosteric mechanisms. Additionally, KG5 exhibits inhibitory activity against Flt3, KIT, and c-Raf. The compound possesses anticancer and antiangiogenic properties [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.88mL

2.18mL

1.09mL

21.77mL

4.35mL

2.18mL
参考文献

[1]Eric A Murphy, et al. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4299-304.