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Polygalacin D

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Chemical Structure| 66663-91-0 同义名 : -
CAS号 : 66663-91-0
货号 : A1371148
分子式 : C57H92O27
纯度 : 98+%
分子量 : 1209.32
MDL号 : MFCD28009141
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(86.83 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Polygalacin D, a natural product isolated and purified from the roots of Polygala tenuifolia Willd, can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2), exhibit significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro, and show hepatoprotective activities against HSC-T6 cell line in vitro.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.83mL

0.17mL

0.08mL

4.13mL

0.83mL

0.41mL

8.27mL

1.65mL

0.83mL
参考文献

[1]Zhan Q, Zhang F, et al. Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells. Molecules. 2012 Dec 13;17(12):14899-907.

[2]Ahn KS, Noh EJ, et al. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Life Sci. 2005 Apr 1;76(20):2315-28.