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Kakuol

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Chemical Structure| 18607-90-4 同义名 : Kakoul
CAS号 : 18607-90-4
货号 : A1371134
分子式 : C10H10O4
纯度 : 98%
分子量 : 194.184
MDL号 : -
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(540.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Kakuol, a natural product isolated and purified from the roots of Asarum sieboldii Miq. with antifungal activity, can completely inhibit the mycelial growth of Botrytis cinerea Pers ex Fr and Cladosporium cucumerinum Ellis & Arthur at 50 microg ml (-1) and 30 microg ml (-1), respectively, and is able to inhibit the DNA relaxation mediated by the human enzyme.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.15mL

1.03mL

0.51mL

25.75mL

5.15mL

2.57mL

51.50mL

10.30mL

5.15mL
参考文献

[1]Castelli S, Vieira S, et al. A derivative of the natural compound kakuol affects DNA relaxation of topoisomerase IB inhibiting the cleavage reaction. Arch Biochem Biophys. 2013 Feb 1;530(1):7-12.

[2]Lee JY, Moon SS, Hwang BK. Isolation and antifungal activity of kakuol, a propiophenone derivative from Asarum sieboldii rhizome. Pest Manag Sci. 2005 Aug;61(8):821-5.