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benzoylpaeoniflorin

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Chemical Structure| 38642-49-8 同义名 : -
CAS号 : 38642-49-8
货号 : A136991
分子式 : C30H32O12
纯度 : 98%
分子量 : 584.568
MDL号 : MFCD00869479
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(179.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Benzoylpaeoniflorin (BP) is a potential therapeutic agent against oxidative stress related Alzheimer's disease[3]. TGP (The totally-amounted glucosides of paeony), which are made up of paeoniflorin, albiflorin, oxypaeoniflorin as well as benzoylpaeoniflorin) treatment lessened the behavior-based loss shown "in the spontaneous motor activity as well as the potential of falling to rotarod test". Pretreatment with TGP markedly improved motor coordination, striatal dopamine and its metabolite levels. TGP can enhance dopaminergic neuron's cell survival in the SNpc in virtue of the activated cAMP/PKA/CREB factor of growth on inhibiting the pathway of second messenger apoptosis as well[4]. TGP has some superior features with immune regulation, gentle effect, many indications and few adverse drug reactions. TGP may be a promising anti-inflammatory and immune drug with soft regulation and has more superiority in the treatment of AIDs[5]. Additionally, paeoniflorin, benzoylpaeoniflorin, mudanpioside C and paeonol can effectively block voltage-operated Ca2+ channels (VOCCs) to exert calcium antagonism[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.71mL

0.34mL

0.17mL

8.55mL

1.71mL

0.86mL

17.11mL

3.42mL

1.71mL
参考文献

[1]Kong M, Liu HH, et al. Quantitative evaluation of Radix Paeoniae Alba sulfur-fumigated with different durations and purchased from herbal markets: simultaneous determination of twelve components belonging to three chemical types by improved high performance liquid chromatography-diode array detector. J Pharm Biomed Anal. 2014 Sep;98:424-33.

[2]Zhu X, Fang ZH. New monoterpene glycosides from the root cortex of Paeonia suffruticosa and their potential anti-inflammatory activity. Nat Prod Res. 2014;28(5):301-5.

[3]Zhou C, Wang X. Rapid Determination of Isomeric Benzoylpaeoniflorin and Benzoylalbiflorin in Rat Plasma by LC-MS/MS Method. Int J Anal Chem. 2017;2017:1693464

[4]Zheng M, Liu C, Fan Y, Shi D, Jian W. Total glucosides of paeony (TGP) extracted from Radix Paeoniae Alba exerts neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the cAMP/PKA/CREB signaling pathway. J Ethnopharmacol. 2019;245:112182

[5]Zhang L, Wei W. Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol Ther. 2020;207:107452

[6]Lu Y, Deng Y, Liu W, Jiang M, Bai G. Searching for calcium antagonists for hypertension disease therapy from Moutan Cortex, using bioactivity integrated UHPLC-QTOF-MS. Phytochem Anal. 2019;30(4):456-463