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PS372424 HCl

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Chemical Structure| 1596362-29-6 同义名 : PS372424 hydrochloride
CAS号 : 1596362-29-6
货号 : A1365951
分子式 : C33H45ClN6O4
纯度 : 98%+
分子量 : 625.201
MDL号 : MFCD28016588
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(399.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PS372424 HCl, a three amino acid fragment from CXCL10, is a specific hCXCR3 agonist with anti-inflammatory activity. In a humanised arthritis model, PS372424 HCl prevents human T cell migration[1][2].After 5 minutes of stimulation, PS372424 HCl (100 nM/ml) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells[1].Acting in the 10-200 nM concentration range for 30 minutes, PS372424 HCl causes concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells, but not on CXCR3- T cells[2].PS372424 HCl competes for the binding of radiolabelled CXCL10 to HEK293/CXCR3 Gqi5 cell membranes with an IC50 of 42±21 nM[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.00mL

1.60mL

0.80mL

15.99mL

3.20mL

1.60mL
参考文献

[1]Boyé K, et al. The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors. Nat Commun. 2017 Nov 17;8(1):1571.

[2]O'Boyle G, et al. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4598-603.

[3]Stroke IL, et al. Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries. Biochem Biophys Res Commun. 2006 Oct 13;349(1):221-8.