生物活性 | |||
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描述 | MSA-2, a powerful orally available non-nucleotide STING agonist, binds to STING as a noncovalent dimer with nanomolar affinity. It displays EC50 values of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 promotes interferon-β secretion in tumors, leads to tumor regression with lasting antitumor immunity, and enhances the effectiveness of anti-PD-1 therapy in syngeneic mouse tumor models[1][2]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.40mL 0.68mL 0.34mL |
16.99mL 3.40mL 1.70mL |
33.98mL 6.80mL 3.40mL |
参考文献 |
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