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Tuxobertinib

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Chemical Structure| 2414572-47-5 同义名 : BDTX-189
CAS号 : 2414572-47-5
货号 : A1365630
分子式 : C29H29ClN6O4
纯度 : 98%
分子量 : 561.031
MDL号 : MFCD32878264
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(71.3 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • EGFR/ErbB1

    EGFR, Kd:0.2 nM

  • HER2/ErbB2

    HER2, Kd:0.76 nM
描述 Tuxobertinib (BDTX-189) serves as a powerful, orally administered, selective inhibitor targeting allosteric EGFR and HER2 oncogenic mutations, notably EGFR/HER2 exon 20 insertion mutants. It demonstrates dissociation constants (KDs) of 0.2, 0.76, 13, and 1.2 nM for EGFR, HER2, BLK, and RIPK2, respectively, and exhibits anticancer activity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.78mL

0.36mL

0.18mL

8.91mL

1.78mL

0.89mL

17.82mL

3.56mL

1.78mL
参考文献

[1]Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.