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Lixumistat acetate

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Chemical Structure| 1422365-94-3 同义名 : IM156;HL156A;HL271 acetate
CAS号 : 1422365-94-3
货号 : A1365556
分子式 : C15H20F3N5O3
纯度 : 99%+
分子量 : 375.346
MDL号 : MFCD32701937
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(133.21 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Lixumistat acetate, a chemical derivative of Metformin, is a potent and orally active activator of AMP-activated protein kinase (AMPK), leading to increased AMPK phosphorylation. Lixumistat (acetate) mitigates aging-related cognitive impairment in animal models [1][2]. Lixumistat (acetate) is a potent inhibitor of oxidative phosphorylation (OXPHOS) suitable for solid tumor research [3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.32mL

2.66mL

1.33mL

26.64mL

5.33mL

2.66mL
参考文献

[1]Row H, et al. HL271, a novel chemical compound derived from metformin, differs from metformin in its effects on the circadian clock and metabolism. Biochem Biophys Res Commun. 2016 Jan 15;469(3):783-9.

[2]Bang E, et al. The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. Exp Neurobiol. 2018 Feb;27(1):45-56.

[3]Sun Young Rha, et al. Phase I study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology 38(15_suppl):3590-3590.