产品说明书
KY19382
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同义名 : | A3051 |
| CAS号 : | 2226664-93-1 | |
| 货号 : | A1365458 | |
| 分子式 : | C17H11Cl2N3O2 | |
| 纯度 : | 98%+ | |
| 分子量 : | 360.194 | |
| MDL号 : | MFCD32878265 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 3 mg/mL(8.33 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | KY19382 is a potent dual inhibitor of CXXC5-DVL and GSK3β, exhibiting IC50s of 19 and 10 nM, respectively. It activates Wnt/β-catenin signaling by inhibiting both the CXXC5-DVL interaction and GSK3β activity. KY19382 is suitable for investigating high fat diet (HFD)-induced metabolic diseases[1][2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.78mL 0.56mL 0.28mL |
13.88mL 2.78mL 1.39mL |
27.76mL 5.55mL 2.78mL |
| 参考文献 |
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