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I3MT-3

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Chemical Structure| 459420-09-8 同义名 : HMPSNE
CAS号 : 459420-09-8
货号 : A1365373
分子式 : C17H14N2O2S
纯度 : 99%+
分子量 : 310.37
MDL号 : MFCD00066363
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(386.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor targeting 3-Mercaptopyruvate sulfurtransferase (3MST) with an IC50 value of 2.7 µM. It shows no activity against other H2S/sulfane sulfur-producing enzymes. I3MT-3 specifically interacts with a persulfurated cysteine residue in the active site of 3MST[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.22mL

0.64mL

0.32mL

16.11mL

3.22mL

1.61mL

32.22mL

6.44mL

3.22mL
参考文献

[1]Kenjiro Hanaoka, et al. Discovery and Mechanistic Characterization of Selective Inhibitors of H 2 S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. Sci Rep. 2017 Jan 12;7:40227

[2]Fiona Augsburger, et al. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells. Biomolecules. 2020 Mar 13;10(3):447.