产品说明书

T025

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Chemical Structure| 2407433-00-3 同义名 : -
CAS号 : 2407433-00-3
货号 : A1365253
分子式 : C21H18N8
纯度 : 99%+
分子量 : 382.421
MDL号 : MFCD31813666
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 7 mg/mL(18.3 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 T025 is a potent, orally active inhibitor of Cdc2-like kinases (CLKs) with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5, and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B, and DYRK2, respectively. T025 induced caspase-3/7-mediated apoptosis in MDA-MB-468 cells at concentrations of 0, 10, 30, 100, 300 and 1000 nM for 6 h. T025 exhibited antiproliferative activity in both haematological and solid cancer cell lines tested (IC50 values: 30-300 nM). It has antitumour efficacy and is mainly used in MYC-driven disease studies[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.07mL

2.61mL

1.31mL

26.15mL

5.23mL

2.61mL
参考文献

[1]Iwai K, et al. Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability. EMBO Mol Med. 2018 Jun;10(6):e8289.