IMP-1088

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Chemical Structure| 2059148-82-0 同义名 : -
CAS号 : 2059148-82-0
货号 : A1365252
分子式 : C25H29F2N5O
纯度 : 98%+
分子量 : 453.527
MDL号 : MFCD32708500
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(231.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 IMP-1088 is a potent dual inhibitor of HsNMT1/2 with IC50 values of less than 1 nM, and the Kd value of IMP-1088 against HsNMT1 is less than 210 pM. IMP-1088 effectively blocks rhinovirus replication by blocking the N-myristoylation of rhinovirus-encoded protein (VP0). IMP-1088 protects host cells from cytotoxicity caused by viral infection. At concentrations less than 1000 nM, IMP-1088 prevented virus-induced cytopathic effects in a dose-dependent manner, with IC50 values of 17 nM, respectively, and at a concentration of 125 nM, IMP-1088 completely inhibited newly infected viruses, with an IC50 value of 5.8 nM. IMP-1088 blocks infectious virus production and inhibits single-cycle replication 7 hours after infection of primary human bronchial epithelial cells (hBEC) with rhinovirus RV-A1 (MOI 5). IMP-1088 significantly inhibits the production of infectious virus even within 3 hours of infection[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

11.02mL

2.20mL

1.10mL

22.05mL

4.41mL

2.20mL
参考文献

[1]Aurélie Mousnier, et al. Fragment-derived Inhibitors of Human N-myristoyltransferase Block Capsid Assembly and Replication of the Common Cold Virus. Nat Chem. 2018 Jun;10(6):599-606.