ZZW-115
产品说明书
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同义名 : | - |
| CAS号 : | 801991-87-7 | |
| 货号 : | A1365243 | |
| 分子式 : | C24H31F3N4S | |
| 纯度 : | 99% | |
| 分子量 : | 464.59 | |
| MDL号 : | MFCD34469422 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | ZZW-115 is a potent NUPR1 inhibitor with a Kd value of 2.1 μM. ZZW-115 induces tumour cell death through necrosis and apoptosis[1][2].ZZW-115 was effective in killing cancer cells in the concentration range of 0.1-33 μM for 72 h. The IC50 of ZZW-115 ranged from 0.84 μM (ANOR) to 4.93 μM (HN14). ZZW-115 induced necrosis and apoptosis of pancreatic cells, and during its action, it caused a decrease in the production of ATP and induced the overproduction of ROS. LDH release from ZZW-115-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b and HN14 cells) was significantly higher than that from control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity was higher in ZZW-115-treated cells. These experiments suggest that ZZW-115 also has a pro-apoptotic effect[1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.15mL 0.43mL 0.22mL |
10.76mL 2.15mL 1.08mL |
21.52mL 4.30mL 2.15mL |
| 参考文献 |
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