Neticonazole
产品说明书
 |
同义名 : | SS717 |
| CAS号 : | 130726-68-0 | |
| 货号 : | A1365146 | |
| 分子式 : | C17H22N2OS | |
| 纯度 : | 99%+ | |
| 分子量 : | 302.434 | |
| MDL号 : | MFCD00868954 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 250 mg/mL(826.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 1M HCl: 100 mg/mL(330.65 mM)，配合低频超声，并调节pH至1 |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Neticonazole, an imidazole derivative, is a potent and long-acting antifungal agent. Neticonazole has anti-infective and anticancer effects[1][2][3].In C4-2B cells, Neticonazole reduced the levels of Alix and Rab27a and significantly reduced the levels of nSMase2 at a concentration of 10 µM for 48 h. Neticonazole significantly inhibited the levels of p-ERK[2].Neticonazole inhibits exosome release from C4-2B cells in a dose-dependent manner over a concentration range of less than 10 µM[2].Neticonazole is also an orally active inhibitor of exosome biogenesis and secretion[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.31mL 0.66mL 0.33mL |
16.53mL 3.31mL 1.65mL |
33.07mL 6.61mL 3.31mL |
| 参考文献 |
|---|