产品说明书

BAY-1797

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Chemical Structure| 2055602-83-8 同义名 : -
CAS号 : 2055602-83-8
货号 : A1364936
分子式 : C20H17ClN2O4S
纯度 : 99%+
分子量 : 416.878
MDL号 : MFCD32689580
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(599.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BAY-1797 is a potent, orally bioavailable, and selective antagonist of P2X4, exhibiting an IC50 of 211 nM against human P2X4. It has little to no activity on other P2X ion channels. BAY-1797 demonstrates anti-nociceptive and anti-inflammatory properties[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

11.99mL

2.40mL

1.20mL

23.99mL

4.80mL

2.40mL
参考文献

[1]Werner S, et al. Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile. J Med Chem. 2019 Dec 26;62