产品说明书
TCH-165
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同义名 : | - |
| CAS号 : | 1446350-60-2 | |
| 货号 : | A1364845 | |
| 分子式 : | C39H37N3O3 | |
| 纯度 : | 98% | |
| 分子量 : | 595.729 | |
| MDL号 : | MFCD31915307 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(419.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | TCH-165 is a small molecule modulator of proteasome assembly that increases the level of 20S and promotes 20S-mediated protein degradation. TCH-165 inhibited the growth of RPMI8226 and U87MG cells at concentrations of 0.01-10 μM for 72 h with IC50s of 1.6 μM and 2.4 μM, respectively.TCH-165 enhanced chymotrypsin-like (CT-L), trypsin-like (Tryp-L), and dendritic enzyme-like (Casp-L) activities with EC50s of 4.2 μM, 3.2 μM, and 4.2 μM, respectively. 4.2 μM, 3.2 μM and 4.7 μM, respectively[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.68mL 0.34mL 0.17mL |
8.39mL 1.68mL 0.84mL |
16.79mL 3.36mL 1.68mL |
| 参考文献 |
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