产品说明书
ASTX029
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同义名 : | - |
| CAS号 : | 2095719-92-7 | |
| 货号 : | A1362224 | |
| 分子式 : | C29H31ClFN5O5 | |
| 纯度 : | 99%+ | |
| 分子量 : | 584.038 | |
| MDL号 : | MFCD32874105 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(428.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | The Ras/Raf/MAPK (MEK)/ERK pathway is the most important signalling cascade among all MAPK signal transduction pathways, and plays a crucial role in the survival and development of tumour cells. The extracellular signal-regulated kinases ERK1 and ERK2 are evolutionarily conserved, ubiquitous serine-threonine kinases that regulate cellular signalling under both normal and pathological conditions. ASTX029 is a synthetic small molecule inhibitor of extracellular signal-regulated kinases ERK1/2. ASTX-029 inhibits the proliferation and survival of ERK-dependent tumor cells[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.71mL 0.34mL 0.17mL |
8.56mL 1.71mL 0.86mL |
17.12mL 3.42mL 1.71mL |
| 参考文献 |
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