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FTI-277 HCl

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Chemical Structure| 180977-34-8 同义名 : FTI-277 hydrochloride
CAS号 : 180977-34-8
货号 : A136104
分子式 : C22H30ClN3O3S2
纯度 : 98%
分子量 : 484.075
MDL号 : MFCD28385886
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(216.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(206.58 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • Transferase

    FTase, IC50:500 pM
描述 FTI-277, when used at 20 micrometers for 48 hours before irradiation, notably decreases the survival of radioresistant HeLa 3A cells expressing a 24-kDa isoform but does not affect the survival of control HeLa PINA cells. This radiosensitizing effect of FTI-277 is accompanied by an increase in postmitotic cell death in HeLa 3A cells and a decrease in G(2)/M phase arrest in both cell lines[1]. GGTI-298 and FTI-277 treatments hinder migration and invasion of PC-3 cells in both time- and dose-dependent manners[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.07mL

0.41mL

0.21mL

10.33mL

2.07mL

1.03mL

20.66mL

4.13mL

2.07mL
参考文献

[1]Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152(4):404-11.

[2]Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633.

[3]Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34(8):815-26.