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Ceapin-A7

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Chemical Structure| 2323027-38-7 同义名 : -
CAS号 : 2323027-38-7
货号 : A1360823
分子式 : C20H12F6N4O3
纯度 : 99%+
分子量 : 470.325
MDL号 : MFCD31567506
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(223.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER (endoplasmic reticulum) stress. Ceapin-A7 is a potent and selective inhibitor of ATF6α signaling in response to ER stress with an IC50 of 0.59 μM. Ceapin-A7 sensitized cells to ER stress. U2-OS cells co-incubated with both Tg and Ceapin-A7 showed an almost two-fold increase in sensitivity to ER stress (IC50 = 4.5 nM). Ceapin (0.6-18.9 μM; 4.5 hours) selectively inhibited ATF6α but not ATF6β[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.63mL

2.13mL

1.06mL

21.26mL

4.25mL

2.13mL
参考文献

[1]Gallagher CM, et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. Elife. 2016 Jul 20;5:e11878