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TMBIM6 antagonist-1

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Chemical Structure| 123134-61-2 同义名 : -
CAS号 : 123134-61-2
货号 : A1359467
分子式 : C15H12N2O3
纯度 : 99%+
分子量 : 268.267
MDL号 : MFCD32858323
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(186.38 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TMBIM6 is a Ca2+ channel-like protein that lowers the steady-state [Ca2+]ER. Overexpression of TMBIM6 promotes cancer metastasis by regulating cell mobility and invasiveness and glucose metabolism. TMBIM6 antagonist-1 is a potential TMBIM6 antagonist which prevents TMBIM6 binding to mTORC2, thus decreases mTORC2 activity, and it also regulates TMBIM6-leaky Ca2+. TMBIM6 antagonist-1 (BIA, 0.5-10 μM, 3 days) significantly and dose-dependently inhibited cell viability in HT1080, MCF7, MDA-MB-2341 and SKBR3 cells, with IC50 values of 1.7 ± 0.1 μM, 2.6 ± 0.4 μM, 2.6 ± 0.5 μM and 2.4 ± 0.4 μM, respectively. TMBIM6 antagonist-1 (BIA, 10 μM) treatment decreased cell migration in HT1080, MCF7, MDA-MB-231, and SKBR3 cells. In vivo, TMBIM6 antagonist-1 (1 mg/kg, IP 5 days per week during 25 days) significantly impaired cell-driven tumor growth in Six- to eight-week BklNbt:BALB/c/nu/nu old mice[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.73mL

0.75mL

0.37mL

18.64mL

3.73mL

1.86mL

37.28mL

7.46mL

3.73mL
参考文献

[1]Kim HK, et al. TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation. Nat Commun. 2020 Aug 11;11(1):4012